Fig. 1.

Plasma concentration of lorcaserin alone, cocaine alone, and cocaine in combination with lorcaserin. Lorcaserin and cocaine were administered at doses of 3.2 mg/kg intragastrically and 1 mg/kg intravenously, respectively. The inset shows the pharmacokinetic profile of lorcaserin, administered alone and immediately after the collection of the first blood sample (0 minutes), with each filled circle representing the mean (± 1 S.E.M.) plasma concentration of lorcaserin in nanograms per milliliter (n = 4). The main panel shows the pharmacokinetic profile of cocaine 90 minutes after administration of either saline (gray circles) or lorcaserin (open squares); cocaine was administered immediately after the collection of the first blood sample (0 minutes). The symbols represent the mean (± 1 S.E.M.) plasma concentration of cocaine in nanograms per milliliter (n = 3). IG, intragastric; IV, intravenous.