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. 2016 Jan;356(1):85–95. doi: 10.1124/jpet.115.228833

Fig. 4.

Fig. 4.

Acute effects of lorcaserin in three monkeys (MU, DU, and LA) discriminating 0.178 mg/kg cocaine intravenously from saline. Gray-filled circles represent the mean (± 1 S.E.M.) percentage of responding that occurred on the cocaine-appropriate lever during test sessions in which saline was administered 90 minutes before saline (S) or the first dose of cocaine. Open squares represent the percentage of responding on the cocaine-associated lever during tests in which lorcaserin was administered before sessions (details available in the Materials and Methods). Open circles represent the mean (± 1 S.E.M.) percentage of responding on the cocaine-associated lever during tests in which 1 mg/kg lorcaserin was administered 75 minutes before cumulative doses of cocaine. IG, intragastric; IV, intravenous.