Fig. 6.

Effects of repeated lorcaserin administration on cocaine self-administration. Plotted are the mean (± 1 S.E.M.) number of infusions delivered of 0.032 mg/kg cocaine (left; n = 5) and the mean (± 1 S.E.M.) rates of responding (right) during 14 consecutive sessions in which lorcaserin (0.1–3.2 mg/kg intragastrically) was administered as a 90-minute pretreatment (open symbols). Gray-filled symbols represent data obtained during the block of seven consecutive sessions that immediately followed lorcaserin treatment, of which saline was administered 90 minutes beforehand. Gray-shaded areas represent the mean (± 1 S.E.M.) for the average number of cocaine infusions (left) and rates of responding (right) during the seven baseline sessions that immediately preceded lorcaserin treatment. PT, pretreatment; Resp, response.