Fig. 7.

Effects of increasing the unit dose of cocaine available for self-administration during 15 consecutive sessions, each preceded by administration of 3.2 mg/kg lorcaserin intragastrically Gray-filled circles represent the mean (± 1 S.E.M.) for the average number of cocaine infusions delivered and rates of responding during five consecutive sessions in which saline was administered as a 90-minute pretreatment (n = 4). Open squares represent the mean (± 1 S.E.M.) for the average number of cocaine infusions and rates of responding during five consecutive sessions preceded by 3.2 mg/kg lorcaserin (90-minute pretreatment). Black-filled symbols represent points that were significantly different from baseline (P < 0.05), as determined by post hoc Holm–Sidak tests. IG, intragastric; Resp, response.