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. 2016 Jan;356(1):106–115. doi: 10.1124/jpet.115.229054

Fig. 6.

Fig. 6.

Genetic ablation of eNOS suppresses caffeine antagonism of ethanol-induced cerebral artery constriction. Averaged data showing that the antagonism exerted by caffeine presence on ethanol action is lost in eNOS KO−/− mice while preserved in wild-type (C57BL/6) mice. Hollow bars present data from arteries from C57BL/6 mice (n = 4); black bars show data from arteries from eNOS KO−/− mice on a C57BL/6 background (n = 4). *Different from constriction by 50 mM ethanol in arteries from control (P<0.05); **(P<0.01); NS, not significant.