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. 2016 Jan 6;6:18899. doi: 10.1038/srep18899

Figure 6. Aliskiren increased insulin sensitivity and upregulated expression levels of PPARα and CPT1a in muscle with reduction in Ang II-associated oxidative stress.

Figure 6

(a) immunohistochemical images of type4 glucose transporter (GLUT4), phosphor-insulin receptor substrate 1 (p-IRS-1), and phosphor-Akt in the gastrocnemius muscle (scale bar = 100 μm). (b) immunohistochemical images of angiotensin II (Ang II), phosphorylated p47 (pp47), and 4-hydroxynonenal (4HNE) (scale bar = 100 μm), and (c) RT-PCR of PPARα/γ1/γ2, CPT1a, AOX, and CYP4A14 in the HFD-V and HFD-Ali groups. The results expressed were relative to the HFD-V group, which was arbitrarily assigned a value of 1. *p < 0.05 vs. the HFD-V group; **p < 0.01 vs. the HFD-V group.