Fig. 6.

TSEC treatment inhibited the progression of ectopic lesions in mice with surgically induced endometriosis. (A and B) Ectopic lesions were isolated from each group of mice treated with different hormones (A), and then the lesion volumes were calculated and presented graphically (n = 5/group) (B). (C) Hematoxylin and eosin analyses of ectopic lesions treated with each ligand in (A). (D–F) Expression levels of Ki-67 (D), ERα (E), and FBXO45 (F) in each type of ectopic lesion described in (A) were determined using immunohistochemistry and are shown in the graph (n = 9/group). (G) Expression levels of FBXO45 in eutopic endometrium treated with each hormone were determined using Western blot analyses and are shown in the graph. *P < 0.05; **P < 0.01; ***P < 0.001. NS, nonspecific versus control, Student’s t test.