Table 1. Glucogenic and ketogenic amino acids levels in liver, skeletal muscle and plasma samples from Atg5-flox (Atgf/f) and liver-specific Atg5-deficient (L-Atg5−/−) mice after 36 h starvation.
| Atg5f/f (n = 7) | L-Atg5−/− (n = 7) | Student’s t test | |
|---|---|---|---|
| Liver (pmol/mg) | |||
| Leucine | 226.1 ± 37.2 | 351.8 ± 79.0 | n.s. |
| Lysine | 541.3 ± 195.2 | 470.2 ± 134.1 | n.s. |
| Isoleucine | 100.7 ± 15.6 | 190.8 ± 60.0 | n.s. |
| Phenylalanine | 58.9 ± 5.0 | 81.1 ± 27.6 | n.s. |
| Tyrosine | 66.5 ± 9.8 | 82.5 ± 28.9 | n.s. |
| Tryptophan | 17.7 ± 1.9 | 20.7 ± 4.0 | n.s. |
| Skeletal muscle (pmol/mg) | |||
| Leucine | 250.4 ± 43.4 | 312.3 ± 40.5 | n.s. |
| Lysine | 470.8 ± 73.3 | 460.7 ± 117.5 | n.s. |
| Isoleucine | 141.4 ± 14.4 | 151.4 ± 19.1 | n.s. |
| Phenylalanine | 108.4 ± 10.7 | 128.0 ± 20.8 | n.s. |
| Tyrosine | 105.5 ± 12.3 | 138.4 ± 40.0 | n.s. |
| Tryptophan | 27.5 ± 1.5 | 31.9 ± 4.6 | n.s. |
| Plasma (μM) | |||
| Leucine | 214.1 ± 37.0 | 339.4 ± 35.7 | P < 0.05 |
| Lysine | 240.0 ± 46.2 | 179.3 ± 18.6 | n.s. |
| Isoleucine | 109.7 ± 12.2 | 145.5 ± 10.6 | P < 0.05 |
| Phenylalanine | 81.1 ± 4.9 | 91.4 ± 8.6 | n.s. |
| Tyrosine | 63.6 ± 9.1 | 69.6 ± 9.7 | n.s. |
| Tryptophan | 66.3 ± 4.9 | 77.4 ± 4.4 | n.s. |
n.s. indicates not statistically significant.