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. 2016 Jan 6;6:18982. doi: 10.1038/srep18982

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(A) Timeline of the experiment. 10 days after LVSIRT6-GFP or LV_GFP infusions, all of the rats were decapitated for subsequent protein assessment. (B) Representative western blot showing decreased expression and phosphorylation of IGF signaling-related proteins after SIRT6 overexpression in the CA1. *p < 0.05, **p < 0.01, compared with LVGFP group.