Table 2. Assessment of drug-like properties of the lead molecules and wortmanin as verified by Qikprop.

Compound	MWa	HDb	HAc	QPlogPo/wd	PHOAe
6	530.62	0	11.15	3.89	86.15
9	268.28	3	6.50	1.04	76.51
12	246.19	3	6.50	−0.93	42.63
13	397.44	2	8.00	2.60	78.29
17	310.32	7	7.00	−0.49	36.24
18	385.34	1	8.20	1.35	64.90
20	314.75	0	5.50	2.39	93.30
21	270.27	0	6.00	1.17	85.13
25	369.44	0	6.20	3.54	100.00
26	364.38	1	6.00	3.46	100.00
27	356.39	2	6.25	2.85	88.63
33	424.67	3	6.00	2.94	77.19
36	471.34	2	9.00	3.80	95.70
37	256.26	0	3.75	2.78	100.00
40	436.55	3	5.50	5.13	100.00
Wortmaninf	428.44	3	13.40	0.31	39.30

^aMolecular weight (256.26–530.62).

^bHydrogen bond donors (<5).

^cHydrogen bond acceptors (<10).

^dPredicted octanol/water partition co-efficient logP (recommended range: −2.0 to 6.5).

^ePercentage of human oral absorption (<25% is poor and >80% is high).

^fUsed as a positive control compound.