Table 4.

Measure of Parent-Rated Strengths and Difficulties from Baseline to the Second Treatment Phase (On 2) of Trial

	Baseline		On 2		Comparing mean differences from baseline to On 2 phase
SDQ-subscales	Mean	SEM	Mean	SEM	MD	MD 95% CI	ES	ES 95% CI	t test
Total Difficulties	19.57	1.44	13.64	1.49	5.93	3.20–8.66	1.09	0.53–1.95	4.69**
Emotional Symptoms	2.21	0.43	1.86	0.56	0.36	−0.77–1.48	0.19	−0.35–0.71	0.69
Conduct Problems	4.43	0.71	2.07	0.47	2.36	1.06–3.65	1.05	0.38–1.70	3.94**
Hyperactivity	8.71	0.38	6.36	0.57	2.36	1.41–3.31	1.29	0.66–2.18	5.36**
Peer Problems	4.21	0.54	3.36	0.57	0.86	−0.42–2.14	0.41	−0.16–0.92	1.45
Prosocial Behavior	6.07	0.72	6.64	0.78	−0.57	−1.11–0.03	0.20	0.03–1.17	−2.28*
Impact Score	6.14	0.57	2.21	0.58	3.93	2.29–5.57	1.83	0.63–2.11	5.17**

SDQ = Strength and Difficulties Questionnaire, which consists of five subscales: Emotional Symptoms Scale, Conduct Problems Scale, Hyperactivity Scale, Peer Problems Scale and Prosocial Scale. The Total Difficulties score is generated by summing the scores from all of the scales except the prosocial scale. For all the subscales except for Prosocial Behavior, a decrease in scores is indicative of improvement in behavior/symptoms; as such, all changes are in the desired direction.

SEM = standard error of the mean; MD = mean difference of On 2 compared with baseline; MD 95% CI = 95% confidence interval of the mean difference; ES = Cohen's d (as for Table 3); ES 95% CI = 95% confidence interval of the Cohen's d.

^*Statistically significant difference at p < 0.05 level.

^**Statistically significant difference at p < 0.01 level.