Table 3.

Drug interactions

Drugs and Interactions
Drugs that increase cinacalcet levels
Ketoconazole, itraconazole, voriconazole, telithromycin, ritonavir
Drugs which decrease cinacalcet levels
Rifampicin
Potential interactions
Stopping or starting cigarette smoking, fluvoxamine, ciprofloxacin
QT interval-affecting drugs (http://www.QTdrugs.org; http://www.sads.org.uk/drugs_to_avoid.htm) in high-risk patients
Dose adjustment required (due to inhibition of cytochrome P450 by cinacalcet) for
Flecainide, propafenone, metoprolol, amitriptyline, desipramine, nortriptyline, clomipramine