Table 4.
Multivariable Cox proportional hazard models predicting survival distribution of time to complete remission
| Variablea | Hazard Ratio (95% Confidence Interval) |
|---|---|
| Proteinuria | |
| UPC<1 g/g | Reference |
| UPC 1–3 g/g | 0.3 (0.2 to 0.5) |
| UPC>3 g/g | 0.3 (0.2 to 0.5) |
| Cohort | |
| MCD | Reference |
| FSGS | 0.2 (0.1 to 0.4) |
| MN | 0.4 (0.2 to 0.9) |
| Other | 0.5 (0.2 to 1.1) |
| Prior IST exposure (overall) | 1.4 (0.9 to 2.2) |
| Prior IST exposure by cohort | |
| MCD, treated | 0.8 (0.3 to 2.2) |
| MCD, untreated | Reference |
| FSGS, treated | 2.5 (1.1 to 5.6) |
| FSGS, untreated | Reference |
| MN, treated | 2.8 (1.0 to 8.2) |
| MN, untreated | Reference |
| Other, treated | 0.8 (0.4 to 1.6) |
| Other, untreated | Reference |
| Prospective IST exposure (overall) | 1.3 (0.9 to 2.1) |
| Prospective IST exposure by cohort | |
| MCD, treated | 1.8 (0.7 to 4.9) |
| MCD, untreated | Reference |
| FSGS, treated | 2.1 (1.0 to 5.1) |
| FSGS, untreated | Reference |
| MN, treated | 0.4 (0.2 to 1.2) |
| MN, untreated | Reference |
| Other, treated | 1.1 (0.6 to 2.1) |
| Other, untreated | Reference |
All patients n=413/188 remissions. Lower hazard ratios indicate a lower likelihood of reaching complete remission. Prior IST exposure refers to medications reported before study baseline visit. UPC, urine protein-to-creatinine ratio; MCD, minimal-change disease; MN, membranous nephropathy; IST, immunosuppression therapy.
a
Significant unadjusted predictors of complete remission (P<0.05) that were removed during multivariable backward selection: family history of kidney disease, family history of hypertension, family history of diabetes, age, weight status (obese versus normal weight), eGFR, LDL cholesterol, and triglycerides.