Table 1.
Clinical characteristics of patients with primary hyperoxaluria who had or did not have ESRD at or before diagnosis
| Characteristics | Without ESRD (n=297) | With ESRD (n=112) | P Value |
|---|---|---|---|
| Type of PH, % (n) | <0.001 | ||
| PH1 | 64.6 (192) | 93.8 (105) | |
| PH2 | 11.8 (35) | 3.6 (4) | |
| PH3 | 12.8 (38) | 0 (0) | |
| Unclassified | 10.8 (32) | 2.7 (3) | |
| Sex, % (n) | 0.05 | ||
| Female | 42.8 (127) | 53.6 (60) | |
| Male | 57.2 (170) | 46.4 (52) | |
| Median age, y | |||
| At diagnosis | 8.1 (4.0, 18.2) | 25.3 (6.8, 42.0) | <0.001 |
| At symptom onset | 4.5 (1.7, 11.3) | 9.4 (2.0, 21.6) | 0.02 |
| Median time between initial symptoms and diagnosis, y | 1.4 (0.1, 7.5) | 3.5 (0.3, 21.0) | <0.001 |
| Median eGFR, ml/min per 1.73 m2 | 73.0 (56.4, 97.5) | 6.6 (3.9, 13.8) | <0.001 |
Median values are expressed with 25th, 75th percentiles. PH, primary hyperoxaluria; PH1, primary hyperoxaluria type 1; PH2, primary hyperoxaluria type 2; PH3, primary hyperoxaluria type 3.