Table 1.
Characteristics of recipients of kidney transplants stratified by recipient age and donor types
| Variables | SCD<60 yr old (n=2411) | ECD<60 yr old (n=650) | SCD Versus ECD P Value | SCD≥60 yr old (n=539) | ECD≥60 yr old (n=222) | SCD Versus ECD P Value |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age at transplant (yr), mean±SD | 44.2±10.2 | 45.1±10.1 | 0.04 | 64.2±3.5 | 64.4±3.4 | 0.35 |
| Men, n (%) | 1518 (63.0) | 437 (67.2) | 0.04 | 341 (63.3) | 136 (61.3) | 0.62 |
| Race, n (%) | <0.01 | 0.73 | ||||
| White | 1881 (78.0) | 474 (72.9) | 469 (87.0) | 191 (86.0) | ||
| Not white | 530 (22.0) | 176 (27.1) | 70 (13.0) | 31 (14.0) | ||
| Patient survival (yr), median (IQR) | 5.8 (2.8–9.0) | 4.6 (1.8–7.8) | <0.001 | 4.2 (1.6–75) | 3.4 (1.5–6.4) | <0.001 |
| Graft survival (yr), median (IQR) | 5.2 (2.1–8.3) | 3.0 (3.0–3.0) | <0.001 | 3.8 (1.4–6.9) | 3.0 (3.0–4.0) | 0.02 |
| Comorbidities at time of first transplant, n (%) | ||||||
| Smoking status | 0.79 | 0.38 | ||||
| Current | 391 (16.2) | 104 (16.0) | 32 (5.9) | 16 (7.2) | ||
| Former | 734 (30.4) | 207 (31.8) | 232 (43.0) | 84 (37.8) | ||
| Never | 1286 (53.3) | 339 (52.2) | 275 (51.0) | 122 (55.0) | ||
| Diabetes mellitus | 322 (13.4) | 90 (13.8) | 0.75 | 86 (16.0) | 27 (12.2) | 0.27 |
| Coronary artery disease | 182 (7.5) | 62 (9.5) | 0.10 | 109 (20.2) | 35 (15.8) | 0.19 |
| Peripheral vascular disease | 111 (4.6) | 43 (6.6) | 0.04 | 49 (9.1) | 16 (7.2) | 0.48 |
| Primary kidney disease, n (%) | 0.75 | 0.45 | ||||
| Diabetes mellitus | 252 (10.7) | 71 (11.0) | 51 (9.6) | 15 (6.9) | ||
| GN | 1199 (50.9) | 326 (50.7) | 231 (43.3) | 110 (50.7) | ||
| Analgesic nephropathy | 13 (0.6) | 2 (0.3) | 17 (3.2) | 9 (4.1) | ||
| Renovascular disease | 88 (3.7) | 31 (4.8) | 54 (10.1) | 19 (8.8) | ||
| Polycystic kidney disease | 355 (15.1) | 89 (13.8) | 114 (21.4) | 39 (18.0) | ||
| Others | 448 (19.0) | 124 (19.3) | 66 (12.4) | 25 (11.5) | ||
| Immunologic status | ||||||
| HLA mismatches, median (IQR) | 3 (2–5) | 3 (3–3) | 0.99 | 3 (2–5) | 3 (3–4) | 0.76 |
| PRA≥85%, n (%) | 130 (5.4) | 34 (5.2) | 0.37 | 16 (3.0) | 11 (5.0) | 0.17 |
| Induction with T cell depletion agent, n (%) | 124 (5.1) | 51 (7.8) | <0.01 | 24 (4.5) | 14 (6.3) | 0.29 |
| No. of rejection episodes, n (%) | <0.01 | 0.17 | ||||
| 0 | 1688 (70.0) | 420 (64.6) | 439 (81.4) | 171 (77.0) | ||
| ≥1 | 723 (30.0) | 230 (35.4) | 100 (18.6) | 51 (23.0) | ||
| Time on dialysis (yr), n (%) | <0.01 | 0.35 | ||||
| 0–1 | 836 (34.7) | 200 (30.8) | 165 (30.6) | 62 (27.9) | ||
| >1–3 | 769 (31.9) | 188 (28.9) | 187 (34.7) | 68 (30.6) | ||
| >3–5 | 388 (16.1) | 127 (19.5) | 82 (15.2) | 38 (17.1) | ||
| >5 | 418 (17.3) | 135 (20.8) | 105 (19.5) | 54 (24.3) | ||
| Transplant era, n (%) | <0.001 | 0.05 | ||||
| 1997–1999 | 534 (22.1) | 125 (19.2) | 100 (18.6) | 37 (16.7) | ||
| 2000–2002 | 643 (26.7) | 121 (18.6) | 118 (21.9) | 33 (14.9) | ||
| 2003–2005 | 541 (22.4) | 145 (22.3) | 128 (23.7) | 52 (23.4) | ||
| 2006–2009 | 693 (28.7) | 259 (39.8) | 193 (35.8) | 100 (45.0) | ||
| Donor information | ||||||
| Donor age, mean±SD | 35.7±14.7 | 62.7±6.4 | <0.001 | 36.6±14.5 | 63.7±7.1 | <0.001 |
| Donor man, n (%) | 1443 (59.9) | 349 (53.7) | <0.01 | 314 (58.3) | 125 (56.3) | 0.62 |
| Preretrieval creatinine (mg/dl), mean±SD | 0.99±0.58 | 1.08±0.85 | <0.01 | 1.06±0.78 | 1.04±0.58 | 0.68 |
| Preretrieval creatinine >1.5 mg/dl, n (%) | 209 (8.9) | 75 (11.7) | 0.03 | 62 (11.8) | 29 (13.4) | 0.55 |
| Donor hypertension, n (%) | 163 (6.9) | 354 (56.1) | <0.001 | 52 (9.9) | 124 (57.4) | <0.001 |
| Cerebrovascular causes of brain death, n (%) | 1042 (43.2) | 543 (83.5) | <0.001 | 251 (46.6) | 185 (83.3) | <0.001 |
| Allograft function | ||||||
| eGFR at 1 yr (ml/min per 1.73 m2), mean±SDa | 55.0±17.4 | 39.9±15.3 | <0.001 | 55.0±17.4 | 41.1±13.7 | <0.001 |
| eGFR at 5 yr (ml/min per 1.73 m2), mean±SDa | 53.5±38.7 | 38.7±16.0 | 55.0±36.2 | 36.2±12.4 | <0.001 | |
| Graft failure, n (%) | 283 (11.7) | 115 (17.7) | <0.001 | 42 (7.8) | 24 (10.8) | 0.18 |
| Death with functional graft, n (%) | 182 (7.5) | 67 (10.3) | 0.02 | 105 (19.5) | 43 (19.4) | 0.29 |
| Cause of mortality, n (%) | 0.15 | 0.28 | ||||
| Cardiovascular | 115 (40.9) | 51 (50.5) | 42 (32.3) | 22 (42.3) | ||
| Malignancy | 60 (21.1) | 24 (23.8) | 40 (30.8) | 9 (17.3) | ||
| Infection | 51 (18.0) | 13 (12.9) | 34 (26.2) | 14 (26.9) | ||
| Others | 57 (20.1) | 13 (12.9) | 14 (10.8) | 7 (13.5) |
SCD, standard criteria deceased donor; ECD, expanded criteria deceased donor; IQR, interquartile range; PRA, panel reactive antibody.
a
eGFR was estimated using the Modification of Diet in Renal Disease equation (9).