Table 3.
Comparisons of urinary biomarkers in AKI-positive and AKI-negative patients at long-term follow-up from cardiopulmonary bypass surgery versus healthy controls
| Variable | A: AKI-Positive Patients (n=30) | B: AKI-Negative Patients (n=18) | C: Healthy Controls (n=90) | D: AKI-Negative Patients and Healthy Controls (n=108) | P Value (Columns A, B, and C)a | P Value (Column A versus Column B) b | P Value (Column A versus Column D)b | P Value (Column B versus Column C)b |
|---|---|---|---|---|---|---|---|---|
| Urine NGAL/Cr, ng/mg | 7.01 (4.03, 9.46) | 15.65 (9.598, 19.213) | 4.81 (2.61, 11.63) | 5.51 (2.96, 15.652) | 0.01 | 0.01 | 0.93 | 0.01 |
| Urine IL-18/Cr, pg/mg | 48.496 (39.05, 70.84) | 20.27 (16.08, 37.16) | 20.68 (14.6, 29.32) | 20.492 (14.917, 29.864) | <0.001 | 0.01 | <0.001 | 0.43 |
| Urine KIM-1/Cr, pg/mg | 619.02 (437.57, 728.88) | 352.407 (231.574, 532.432) | 378.408 (273.164, 545.486) | 378.41 (262.24, 537.55) | 0.01 | 0.03 | 0.002 | 0.63 |
| Urine L-FABP/Cr, ng/mg | 5.88 (4.74, 7.44) n=29 | 3.9 (2.81, 5.4) | 3.07 (1.9, 4.87) | 3.18 (1.9, 5.11) | <0.001 | 0.001 | <0.001 | 0.40 |
Values are expressed as the median (interquartile range). NGAL, neutrophil gelatinase-associated lipocalin; Cr, creatinine; KIM-1, kidney injury molecule-1; L-FABP, liver fatty acid–binding protein.
a
P=0.05.
b
P=0.02 (0.05/n−1; n=4).