Figure 6.

A proposed mechanism of seizure generation in the temporal lobe of patients with MS. A Type I GML together with the associated underlying white matter lesion, evidenced by and in part due to the presence of activated microglia, produce neuronal dysfunction (mitochondrial stress) and cell death (interneuron loss within layer VI). Resulting damage to projecting neurons contributes to the loss of interneurons in layer IV. The resulting loss of inhibition enhances the risk of seizures. Additional stressors including concurrent infection are then more likely to result in the emergence of seizures. MS: multiple sclerosis; GML: grey matter lesion.