Table 3.
Post-operative outcomes of patients with reference to PCC administration
| Overall series | Propensity score–matched pairs | ||||||
|---|---|---|---|---|---|---|---|
| No PCC (n = 680) | PCC (n = 291) | p Value | Propensity score adjusted (OR, 95 % CI or βa, 95 % CI) | No PCC (n = 225) | PCC (n = 225) | p Value | |
| In-hospital mortality | 49 (7.2) | 24 (8.2) | 0.573 | 1.51, 0.84–2.72 | 19 (8.4) | 21 (9.3) | 0.740 |
| Post-operative IABP | 81 (11.9) | 21 (7.2) | 0.029 | 0.61, 0.35–1.09 | 32 (14.2) | 17 (7.6) | 0.023 |
| Inotropes | 559 (82.2) | 217 (74.6) | 0.007 | 0.74, 0.50–1.08 | 182 (80.9) | 170 (75.6) | 0.171 |
| Vasopressors | 177 (26.0) | 92 (31.6) | 0.075 | 1.18, 0.83–1.67 | 67 (29.8) | 71 (31.6) | 0.683 |
| Peri-operative MI | 35 (5.1) | 14 (4.8) | 0.827 | 1.22, 0.58–2.58 | 13 (5.8) | 12 (5.3) | 0.837 |
| Stroke | 38 (5.6) | 20 (6.9) | 0.439 | 1.19, 0.32–5.21 | 9 (4.0) | 14 (6.2) | 0.284 |
| AKI | 159 (23.4) | 91 (31.3) | 0.010 | 1.44, 1.02–2.05 | 60 (26.7) | 68 (30.2) | 0.403 |
| RRT | 8 (1.2) | 9 (3.1) | 0.037 | 3.35, 1.13–9.90 | 4 (1.8) | 8 (3.6) | 0.381 |
| Post-operative AF | 338 (49.7) | 165 (56.7) | 0.046 | 1.34, 0.97–1.84 | 124 (55.1) | 136 (60.4) | 0.252 |
| Resternotomy for bleeding | 114 (16.8) | 42 (14.4) | 0.365 | 0.95, 0.61–1.47 | 42 (18.7) | 33 (14.7) | 0.255 |
| Blood loss, ml | 908 ± 625 | 803 ± 1100 | <0.0001 | −96.5, −222.1 to −29.0 | 935 ± 583 | 836 ± 1226 | <0.0001 |
| RBC transfusion | 619 (91.0) | 243 (83.5) | 0.001 | 0.50, 0.31–0.80 | 210 (93.3) | 189 (84.0) | 0.002 |
| RBC transfusion, U | 4.9 ± 4.5 | 3.4 ± 3.0 | <0.0001 | −1.42, −2.06 to −0.77 | 5.2 ± 4.3 | 3.4 ± 3.1 | <0.0001 |
| RBC transfusion >2 U | 463 (68.1) | 154 (52.9) | <0.0001 | 0.53, 0.38–0.73 | 158 (70.2) | 114 (50.7) | <0.0001 |
| Platelet transfusion | 362 (53.2) | 170 (58.4) | 0.137 | 1.27, 0.92–1.75 | 123 (54.7) | 133 (59.1) | 0.341 |
| Ventilation, h | 82 ± 202 | 68 ± 99 | 0.160 | −6.09, −34.12 to 21.95 | 73.2 ± 98.7 | 68 ± 95 | 0.871 |
| ICU stay, h | 125 ± 175 | 112 ± 122 | 0.191 | −4.34, −1.49 to 0.63 | 128 ± 152 | 110 ± 118 | 0.954 |
| In-hospital stay, days | 13.2 ± 12.1 | 11.4 ± 7.7 | 0.589 | −1.47, −3.20 to 0.27 | 14.1 ± 12.9 | 11.4 ± 7.9 | 0.115 |
MI myocardial infarction, AF atrial fibrillation, AKI acute kidney injury, CI confidence interval, IABP intra-aortic balloon pump, ICU intensive care unit, OR odds ratio, PCC prothrombin complex concentrates, RBC red blood cells, RRT renal replacement therapy
Continuous values are reported as mean and standard deviation; nominal variables are reported as counts (percentages)
aβ value represents the β unstandardised coefficient of the linear regression analysis