Table 1.

Dosing Recommendations for ZA in Pediatric Patients

Diagnosis	Initial Dose, mg/kg	Subsequent Doses, mg/kg	Maximum Single Dose	Dosing Interval
Osteoporosis, low BMD for age	0.0125	0.025–0.05	<18 y, 4 mg; ≥18 y, 5 mg	6–12 mo
AVN, CRMO, fibrous dysplasia	0.0125	0.025–0.05	4 mg	3–12 mo
OI and other genetic bone diseases	0.025	0.025–0.05	<18 y, 4 mg; ≥18 y, 5 mg	6–12 mo
Hypercalcemia of malignancy	0.025	0.025–0.05	4 mg	1–6 wk