Table 2.
Association Between AMH and Fecundability Overall and by Reproductive History
| hCG Pregnancy |
Clinical Pregnancy |
|||||
|---|---|---|---|---|---|---|
| Low AMH <1.0 ng/mL | Normal AMH 1.0–3.5 ng/mL | High AMH >3.5 ng/mL | Low AMH <1.0 ng/mL | Normal AMH 1.0–3.5 ng/mL | High AMH >3.5 ng/mL | |
| Overall (n = 1202) | ||||||
| Achieved pregnancy, n, % | 82 (66.1) | 383 (64.4) | 315 (65.2) | 74 (59.7) | 348 (58.5) | 290 (60) |
| FOR, unadjusted | 1.05 (0.81,1.38) | Referent | 1.09 (0.92, 1.29) | 1.01 (0.77, 1.34) | Referent | 1.09 (0.92, 1.30) |
| FOR, adjusted model 1a | 1.11 (0.84,1.47) | Referent | 1.07 (0.90, 1.27) | 1.06 (0.80, 1.41) | Referent | 1.07 (0.90, 1.28) |
| FOR, adjusted model 2b | 1.14 (0.85,1.52) | Referent | 1.07 (0.90, 1.27) | 1.07 (0.80, 1.44) | Referent | 1.07 (0.90, 1.28) |
| History of no previous live births (n = 561) | ||||||
| Achieved pregnancy, n, % | 33 (60) | 147 (57.6) | 151 (60.2) | 30 (54.5) | 133 (52.2) | 137 (54.6) |
| FOR, unadjusted | 1.02 (0.68, 1.54) | Referent | 1.23 (0.96, 1.58) | 1.03 (0.67, 1.57) | Referent | 1.22 (0.94, 1.59) |
| FOR, adjusted model 1a | 1.14 (0.74, 1.77) | Referent | 1.19 (0.93, 1.54) | 1.15 (0.73, 1.81) | Referent | 1.18 (0.91, 1.54) |
| FOR, adjusted model 2c | 1.18 (0.75, 1.84) | Referent | 1.14 (0.88, 1.47) | 1.19 (0.75, 1.88) | Referent | 1.12 (0.86, 1.47) |
| History of live birth (n = 641) | ||||||
| Achieved pregnancy, n, % | 49 (71) | 236 (69.4) | 164 (70.7) | 44 (63.8) | 215 (63.2) | 153 (65.9) |
| FOR, unadjusted | 1.11 (0.78, 1.60) | Referent | 1.00 (0.80, 1.27) | 1.02 (0.70, 1.48) | Referent | 1.02 (0.80, 1.29) |
| FOR, adjusted model 1a | 1.17 (0.81, 1.69) | Referent | 0.98 (0.77, 1.23) | 1.06 (0.72, 1.54) | Referent | 1.00 (0.78, 1.27) |
| FOR, adjusted model 2c | 1.17 (0.81, 1.70) | Referent | 0.97 (0.77, 1.23) | 1.05 (0.72, 1.54) | Referent | 0.99 (0.78, 1.26) |
| History of one previous loss (n = 804) | ||||||
| Achieved pregnancy, n, % | 54 (65.9) | 244 (62.2) | 214 (64.8) | 51 (62.2) | 223 (56.9) | 196 (59.4) |
| FOR, unadjusted | 1.03 (0.74, 1.44) | Referent | 1.14 (0.93, 1.40) | 1.06 (0.75, 1.49) | Referent | 1.12 (0.91, 1.39) |
| FOR, adjusted model 1a | 1.12 (0.79, 1.59) | Referent | 1.07 (0.90, 1.27) | 1.16 (0.81, 1.67) | Referent | 1.09 (0.88, 1.36) |
| FOR, adjusted model 2c | 1.13 (0.79, 1.60) | Referent | 1.08 0.88, 1.34) | 1.17 (0.81, 1.67) | Referent | 1.06 (0.85, 1.32) |
| History of two previous losses (n = 398) | ||||||
| Achieved pregnancy, n, % | 28 (66.7) | 139 (68.5) | 101 (66) | 23 (54.8) | 125 (61.6) | 94 (61.4) |
| FOR, unadjusted | 1.09 (0.68, 1.74) | Referent | 1.00 (0.74, 1.34) | 0.90 (0.55, 1.47) | Referent | 1.02 (0.75, 1.38) |
| FOR, adjusted model 1a | 1.10 (0.69,1.77) | Referent | 0.99 (0.73,1.33) | 0.90 (0.55,1.47) | Referent | 1.02 (0.75,1.39) |
| FOR, adjusted model 2c | 1.13 (0.70, 1.82) | Referent | 0.96 (0.71, 1.30) | 0.89 (0.54, 1.47) | Referent | 0.99 (0.72, 1.35) |
| Last loss within prior 1 year (n = 946) | ||||||
| Achieved pregnancy, n, % | 10 (47.6) | 68 (54) | 40 (44.4) | 8 (38.1) | 58 (46) | 37 (41.1) |
| FOR, unadjusted | 1.09 (0.81, 1.46) | Referent | 1.18 (0.98, 1.42) | 1.05 (0.78, 1.42) | Referent | 1.05 (0.78, 1.42) |
| FOR, adjusted model 1a | 1.11 (0.82, 1.5) | Referent | 1.17 (0.97, 1.41) | 1.05 (0.77, 1.43) | Referent | 1.15 (0.95, 1.4) |
| FOR, adjusted model 2c | 1.13 (0.84, 1.53) | Referent | 1.14 (0.94, 1.37) | 1.05 (0.77, 1.44) | Referent | 1.12 (0.92, 1.36) |
| Last loss ≥ 1 year prior (n = 237) | ||||||
| Achieved pregnancy, n, % | 71 (69.6) | 306 (66.7) | 270 (70.1) | 65 (63.7) | 282 (61.4) | 248 (64.4) |
| FOR, unadjusted | 0.85 (0.41, 1.77) | Referent | 0.70 (0.46, 1.07) | 0.8 (0.36, 1.77) | Referent | 0.82 (0.52, 1.27) |
| FOR, adjusted model 1a | 0.99 (0.45, 2.16) | Referent | 0.67 (0.44, 1.04) | 1.07 (0.46, 2.47) | Referent | 0.75 (0.48, 1.18) |
| FOR, adjusted model 2c | 1.1 (0.49, 2.46) | Referent | 0.66 (0.42, 1.02) | 1.26 (0.53, 2.98) | Referent | 0.75 (0.47, 1.18) |
FOR presented as estimate (95% confidence interval).
a
Adjusted for age.
b
Adjusted for age, race, BMI, treatment, income, parity, number of previous losses, and time from last loss to randomization.
c
Adjusted for age, race, BMI, treatment, and income.