Table 2.
IGD Gene Expression in Human Tissues
| Tissue Expression Database |
||||||
|---|---|---|---|---|---|---|
| TiGER | BioGPS | Human Protein Atlas (n = 3, 1 Child, 2 Adults) | Riken FANTOM5 (Adult n = 1) | Riken FANTOM5 (Fetal n = 1) | GTEx (n = 22–30 Adults) | |
| Total # Tissue Types | 30 | 78 | 45 | 56 | 20 | 46 |
| Relevant tissue samples | Whole brain | Whole brain fetal brain olfactory bulb prefrontal cortex pituitary hypothalamus | Cerebral cortex lateral ventricle | Diencephalons olfactory apparatus pituitary | Occipital lobe parietal lobe temporal lobe | Frontal cortex hypothalamus pituitary |
| Gene | Expression pattern | |||||
| KAL1 | + | All | Cerebral cortex (RNA) | All | All | Frontal cortex, hypothalamus |
| GNRHR | + | All | − | Pituitary | − | Pituitary |
| GNRH1 | + | All | All | Diencephalon (low) | Parietal (low) | All |
| KISS1 | − | − | − | − | Temporal (low) | − |
| FGFR1 | + | All | All | All low | All low | All |
| FGF8 | Not found | All | − | − | − | Frontal cortex, hypothalamus |
| KISS1R | Not found | All | − | Pituitary (low) | − | Hypothalamus, pituitary |
| TAC3 | + | − | All | All (pituitary low) | All | Frontal cortex, hypothalamus |
| TACR3 | Not found | All | All | Olfactory apparatus (low) | All low | Hypothalamus |
| PROKR2 | Not found | − | All | − | − | All |
| PROK2 | Not found | − | Lateral ventricle (protein) | Diencephalon (low) | Temporal (low) | − |
| SEMA3A | + | All | All | Pituitary (low) | − | All |
| SOX10 | + | Whole brain, olfactory bulb, prefrontal cortex, hypothalamus | All | All low | All | Frontal cortex, hypothalamus |
| AXL | + | All | Cerebral cortex (RNA and protein) | All low | Occipital (low), Temporal | All (low) |
| SEMA3E | + | All | All | All low | All low | Frontal cortex, hypothalamus |
| NSMF (NELF) | Not found | Whole brain, prefrontal cortex | All | All (pituitary low) | All | All |
| WDR11 | Not found | Prefrontal cortex, hypothalamus | All | All low | Occipital, parietal, temporal (low) | All |
| CHD7 | + | All | All | All low | All | All |
| FGF17 | Not found | All | Cerebral cortex (RNA) | − | − | All |
| IL17RD | + | Prefrontal cortex, hypothalamus, olfactory bulb | All | All | All | All |
| HS6ST1 | + | All | Cerebral cortex (RNA) | − | − | All |
| FEZF1 | Not found | − | − | − | − | Hypothalamus |
| SPRY4 | + | All | All | − | Occipital (low), temporal (low) | All |
| FLRT3 | + | − | Cerebral cortex (RNA and protein) | All | All | Frontal cortex, hypothalamus |
| DUSP6 | + | Olfactory bulb | All | All low | Occipital (low), temporal (low) | All |
Expression of the 25 IGD genes according to publically available databases. Only relevant tissue types were examined. TiGER (Tissue-specific Gene Expression and Regulation) (http://bioinfo.wilmer.jhu.edu/tiger/) (107) and BioGPS (http://biogps.org/#goto=welcome) (101) databases integrate data from multiple sources. The Human Protein Atlas (http://www.proteinatlas.org/) (106), FANTOM5 (Riken consortium Functional Annotation of the Mammalian Genome) (103), and GTEx (Genotype-Tissue Expression) (http://www.gtexportal.org/home/) (105) databases contain expression data from multiple tissues taken from human subjects. Data from the FANTOM5 project were obtained indirectly from the EMBL-EBI expression atlas, which compiles expression data from many of these databases (https://www.ebi.ac.uk/gxa/home) (102). +, expressed; −, not expressed; not found, expression not examined; (low), expression was just detectable.