Figure.

Panel A – A montage of fundus photographs from the right eye of a 19 year old patient affected with autosomal dominant retinitis pigmentosa caused by a heterozygous Gly114Asp variation in the rhodopsin gene. The “bone-spicule-like” pigmentation that gives the condition its name is most prominent anterior to the major vascular arcades.

Panel B – Higher magnification view of the macula of the same eye shown in panel A. The retinal arterioles (arrowheads) have vasoconstricted in response to the high oxygen tension in the retina and are so narrow that they are almost invisible while the venules remain near normal in caliber. Retinal edema is present in the macula and a single large cyst is present in the fovea (arrow).