Table 3.
Model Parameters and Goodness of Fit of the SNP and SNP-signature candidates.
Biomarker Name | Biomarker Status | D50 (90% CI) (Gy) | λ (90% CI) | k (90% CI) | R2 |
---|---|---|---|---|---|
Single SNP rs238406 | Sensitive | 64.3 (55.4, 77.9) | 22.4 (4.6, ND) | 0.64 (0.49, ND) | 0.12 |
Resistant | 82.7 (70.5, 95.1) | 10.9 (4.3, ND) | 1.0 (0.43, ND) | 0.37 | |
SNP signature | Sensitive | 63.7 (53.5, 66.3) | 50 (6.8, ND) | 0.61 (0.48, ND) | 0.18 |
Resistant | 76.1 (71.3, 84.6) | 19.5 (8.0, ND) | 0.83 (0.59, ND) | 0.49 | |
Mixed group | 67.2 (62.2, 80.8) | 13.8 (4.8, 45) | 0.67 (0.51, ND) | 0.17 |
ND = Not determined due to limited data points