TABLE 2.
Serum NI titers after passive transfer of N1-specific MAbs
| Day of serum collectiona | Serum NI titer against homologous viral NAb |
|||||
|---|---|---|---|---|---|---|
| HF5 | CD6 | 4E9 | 1H5 | 3A2 | PBS | |
| 1 | 5,120 | 2,560 | 5,120 | 640 | >5120 | <10 |
| 3 | 2,560 | 5,120 | 2,560 | 640 | >5120 | <10 |
| 6 | 2,560 | 1,280 | 1,280 | 320 | >5120 | <10 |
| 9 | 2,560 | 1,280 | 640 | 80 | >5120 | <10 |
| 14 | 1,280 | 640 | 80 | 40 | >5120 | <10 |
a
Mouse sera were collected on days 1, 3, 6, 9, and 14 after i.p. injection of each MAb (5 mg/kg) or PBS.
b
NI titers were measured by ELLA with H6N1 reassortant viruses that contained the HA gene of H6N2 virus A/turkey/Massachusetts/3740/1965 and the NA gene of CA/09 virus (H6N1CA/09) or the NA gene of BR/07 virus (H6N1BR/07). Shown are the titers from sera pooled from 3 mice at each time point. Sera from the groups receiving HF5 and CD6 were titrated against H6N1CA/09; sera from the groups receiving 4E9, 1H5, and 3A2 were titrated against H6N1BR/07; sera from the group receiving PBS were titrated against both viruses.