FIG 2.

YY1 deficiency in adipose tissue leads to increased energy expenditure without changes in food intake or physical activity. (A and B) Accumulated food intake measured by CLAMS analysis (A) and by weighing food pellets (B) for individually caged mice at the indicated time points. (C) Total spatial mouse movement in 3 dimensions analyzed by CLAMS. (D and E) Total O₂ consumption and CO₂ production in (D) YY1aKO and (E) YY1bKO mice versus control mice fed a high-fat diet for 2 weeks. Data are represented as means ± SEM. *, P < 0.05, and **, P < 0.01, by t test (n = 8).