FIG 2.
PI sensitivities of wild-type HIV-1, wild-type HIV-2, and HIV-2 PRΔ4. Bars indicate mean EC50s from single-cycle assays in 293T/17 and MAGIC-5A indicator cells, comparing HIV-1NL4-3, HIV-2ROD9, and HIV-2ROD9 containing protease substitutions I32V, V47I, M76L, and I82V (PRΔ4). Error bars indicate standard deviations. Means and standard deviations were determined from three to eight independent assays. *, statistically significant (P < 0.05). ns, not significant. All differences between HIV-1NL4-3 and HIV-2ROD9 are statistically significant, except in the case of saquinavir.