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Proposed model of the underlying molecular mechanism of CMV-reduced trophoblast migration. CMV infection of trophoblasts (1) increases the expression of Wnt5a-mediating receptor ROR2 (2). We propose that this increase in tyrosine kinase receptor ROR2 alters Wnt5a-mediated signaling, which leads to inhibition of canonical Wnt signaling downstream of β-catenin stabilization, at the level of TCF/LEF mediated transcription (3), resulting in reduced trophoblast migration (4).
