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. 2015 Dec 30;90(2):813–828. doi: 10.1128/JVI.01942-15

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Copyright © 2015 Schiffner et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 7 — Properties of GLA cross-linked and PGT145 positively selected B41 SOSIP trimers. (A) SDS-PAGE analysis of unmodified (UM) and cross-linked (GLA) B41 trimers. (B) GLA cross-linked and PGT145-selected B41 was analyzed by capture ELISA. Binding indices were calculated as AUC (cross-linked)/AUC (unmodified). Values of <1 indicate there was a reduction in antibody binding; values of 1 (dotted line) represent no change in binding. Binding indices are shown for all MAbs tested. (C) The MAbs are grouped into neutralizing (bNAbs) and nonneutralizing (non-NAbs) categories; the dotted line represents no change in binding index. *, P < 0.05 Mann-Whitney U test. (D and E) 2D class averages from negative-stain EM analysis of unmodified (D) and GLA-treated and PGT145 selected (E) B41 trimers.