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Inhibition of p38 reduces BGLF2-induced EBV reactivation. (A) AGS-EBV-BGLF2 cells were treated with an inhibitor of p38 (SB202190; 20 μM), JNK (SP600125; 50 μM), or MEK1/2 (U0126; 20 μM) or with DMSO for 2 days, and cell lysates were immunoblotted for BZLF1, BGLF2, and actin. (B) EBV released into the supernatant from the cells in panel A was used to infect Raji cells, and cell lysates were immunoblotted for GFP to measure virus production.
