TABLE 1.
Nucleotide differences among the proposed genotypes of WNV
| Nucleotide positiona | Gene product | Amino acid position | Amino acid at indicated position inb: |
||||
|---|---|---|---|---|---|---|---|
| Reference sequence | NY99 | Intermediate | WN02 | SW03 | |||
| 564 | prM | C | C | C | T | T | |
| 1224 | E | A | A | A | A | G | |
| 1346 | E | 159 | T (Val) | T (Val) | T (Val) | C (Ala) | C (Ala) |
| 1878 | E | C | C | C | C | T | |
| 2370 | E | C | C | C | T | T | |
| 2736 | NS1 | T | T | C | T | T | |
| 3303 | NS1 | T | T | T | T | C | |
| 4050 | NS2A | A | A | G | G | G | |
| 4468 | NS2B | T | T | C | T | T | |
| 4707 | NS3 | C | C | C | T | T | |
| 6042 | NS3 | C | C | T | T | T | |
| 6142 | NS3 | C | C | C | C | T | |
| 6183 | NS3 | G | G | A | G | G | |
| 6330 | NS3 | C | C | T | T | T | |
| 6625 | NS4A | 85 | G (Ala) | G (Ala) | G (Ala) | G (Ala) | A (Thr) |
| 6669 | NS4A | T | T | T | T | C | |
| 6675 | NS4A | A | A | G | A | A | |
| 6840 | NS4B | T | T | T | T | C | |
| 6900 | NS4B | C | C | C | T | T | |
| 6919 | NS4B | T | C | C | C | C | |
| 7066 | NS4B | 83 | G (Ala) | G (Ala) | T (Ser) | G (Ala) | G (Ala) |
| 7113 | NS4B | A | A | A | A | T | |
| 7173 | NS4B | T | T | T | T | C | |
| 7842 | NS5 | T | T | C | C | C | |
| 8454 | NS5 | C | C | C | C | T | |
| 8525 | NS5 | 314 | A (Lys) | A (Lys) | A (Lys) | A (Lys) | G (Arg) |
| 8580 | NS5 | A | A | G | A | A | |
| 8715 | NS5 | T | C | C | C | C | |
| 8742 | NS5 | T | T | C | T | T | |
| 8982 | NS5 | G | G | A | G | G | |
| 9168 | NS5 | T | T | T | T | C | |
| 9256 | NS5 | C | C | C | T | T | |
| 9564 | NS5 | C | C | C | C | T | |
| 9648 | NS5 | T | T | C | T | T | |
| 9966 | NS5 | T | T | T | T | C | |
| 10221 | NS5 | C | C | T | C | C | |
| 10297 | NS5 | C | C | T | C | C | |
a
Nucleotide numbering is in reference to the consensus sequence for each genotype.
b
Position numbering is according to that for the WNV (NY99) reference sequence (GenBank accession number NC_009942). Amino acid substitutions are shown in parentheses.