TABLE 2.
Susceptibility dependence on TSE/prion type and host PrP polymorphism
| Disease type | PrP allotype susceptibilitya |
||
|---|---|---|---|
| Most | Medium | Least | |
| BSE | Wild type | V136 | R171 |
| Classical scrapie | V136 | Wild type | R171 |
| Atypical/Nor98 scrapie | Wild type | R171 | V136 |
a
Susceptibility is presented in a qualitative way for the single amino acid allotype. Wild-type represents the A136R154Q171 allele. Data about BSE are from experimental infections, classical scrapie data are from natural and experimental infections, and atypical/Nor98 scrapie data are from active monitoring in a number of European countries.