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. 2015 Dec 30;54(1):75–82. doi: 10.1128/JCM.02177-15

TABLE 2.

Loss-of-function mutations in the NH/NP sequenced GBS strains

Isolate CSPa STb Mutated gene Type of mutation Size or characteristic DNA positionc Protein positiond
CCH1334 III 17 cylX-D Deletion X1 → D849
CCH1084 III 1 cylX-D Insertion IS1381 X306 → D1
CCH1318 III 17 cylG Substitution Stop codon 636/723 213/241
CCH1338 III 366 cylG Deletion 4 bp 300/723 103/241
CCH1347 III 17 acpC Substitution Stop codon 42/306 15/102
CCH1340 IV 459 cylZ Deletion 1 bp 92/477 55/159
CCH1321 III 106 cylA Insertion IS1381 471/930
CCH1323 III 27 cylA Insertion IS1381 471/930
CCH1337 III 27 cylA Insertion IS1381 466/930
CCH1326 III 17 cylE Deletion 5 bp 241/2004 81/668
CCH1339 Ia 136 cylE Insertion ISSa4 1582/2004
CCH1341 III 17 cylE Substitution Stop codon 1335/2004 446/668
CCH1342 III 27 cylE Insertion 1 bp 897/2004 304/668
CCH1352 III 17 cylE Deletion 1 bp 1514/2004 523/668
CCH1345 II 10 cylF Substitution Stop codon 595/954 199/318
CCH1333 III 17 cylF-I Deletion 692 pb F749 → I492
CCH1319 III 17 cylI Deletion 1 bp 1121/2196 386/732
CCH1320 III 17 cylI Insertion 17 bp 1817/2196 619/732
CCH1322 Ia 23 cylI Deletion 1 bp 883/2196 306/732
CCH1327 II 28 cylI Insertion ICESp1108 1863/2196
CCH1329 II 12 cylI Insertion 1 bp 434/2196 158/732
CCH1343 II 22 cylI Substitution Stop codon 936/2196 313/732
CCH1344 Ib 8 cylI Insertion IS1381 1844/2196
CCH1349 Ib 1 cylI Insertion IS1381 1842/2196
abx1 Deletion 1 bp 176/921 73/307
CCH1346 IV 1 cylI Insertion 12 bp 1172/2196
abx1 Substitution Stop codon 504/921 169/307
CCH1324 V 1 cylI Deletion 83 bp 1893/2196
abx1 Deletion 1 bp 176/921 73/307
CCH1325 III 1 abx1 Deletion 1 bp 176/921 73/307
CCH1330 III 17 abx1 Insertion 1 bp 101/921 53/307
CCH1331 V 1 abx1 Deletion 1 bp 176/921 73/307
CCH1350 V 1 abx1 Deletion 1 bp 176/921 73/307
CCH1328 V 1 abx1 Deletion 1 bp 176/921 73/307
CCH1351 II 2 NDe
CCH1348 IV 459 ND
CCH1336 III 17 ND
a

CSP, capsular serotype.

b

ST, sequence type by MLST.

c

Nucleotidic position of the mutation/wild-type gene length.

d

Amino acid position of the truncation/wild-type protein length.

e

ND, not determined.