Table 1. Target class content.

Targets	UniProt ID count
7TM receptors*	395
Nuclear hormone receptors	48
Catalytic receptors	239
Ligand-gated ion channels	84
Voltage-gated ion channels	141
Other ion channels	47
Enzymes (all)	1164
Transporters	508
Kinases	539
Proteases	240
Other proteins	135
Total number of targets	2761

*Not all our 7TM receptor records are unequivocally assigned as GPCRs, but for convenience we refer to these generally as GPCRs in the text.