Table 4. KEGG contents for antimicrobial resistance.

Category	Content	Example
Pathway map	Drug resistance pathway	map01501 beta-Lactam resistance
		map01502 Vancomycin resistance
Signature modulea	Resistance caused by: (i) altered target site	M00625 Methicillin resistance
	(ii) enzymatic inactivation	M00627 beta-Lactam resistance, Bla system
	(iii) decreased penetration	M00745 Imipenem resistance, repression of porin OprD
	(iv) increased efflux	M00704 Tetracycline resistance, efflux pump Tet38
Signature KOa	Resistance gene mutation groups	Tight KOs for beta-lactamases
Sequence data	Amino acid sequences of known resistance genes	GENES addendum data listed in BRITE table files: br08453 beta-lactamases br08456 tetracyclin resistance genes br08454 aminoglycoside resistance genes br08455 macrolide resistance genes

^aSignature modules and signature KOs are annotated with the threat level defined by CDC

(http://www.cdc.gov/drugresistance/threat-report-2013/) and shown in the BRITE table file

(http://www.kegg.jp/kegg/disease/br08451.html).