Table 2. Information in the MEROPS database.
| MEROPS 9.9 | MEROPS 9.13 | |
|---|---|---|
| Substrate cleavages: total | 61 357 | 64 470 |
| Substrate cleavages: physiological | 16 580 | 17 131 |
| Substrate cleavages: non-physiological | 35 364 | 36 981 |
| Substrate cleavages: pathological | 1235 | 1426 |
| Substrate cleavages: synthetic substrates | 5235 | 5965 |
| Peptidase-inhibitor interactions: total | 4475 | 6202 |
| Peptidase-inhibitor interactions: proteins | 1373 | 1428 |
| Peptidase-inhibitor interactions: SMI | 2790 | 4419 |
| References | 52 600 | 59 155 |
Substrate cleavage totals do not include cleavages derived only from the SwissProt database (mainly removal of initiating methionines and signal peptides). A naturally occurring cleavage is described as ‘physiological’ when the peptidase and substrate are from the same organism, and ‘pathological’ if the organisms differ and are pathogen and host.