Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Nov 20;44(Database issue):D986–D991. doi: 10.1093/nar/gkv1132

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 1. — Database construction and software architecture of mutationaligner.org. (A) Integrated analysis of cancer mutations from TCGA and protein domains from Pfam-A. (B) Identified domain mutation hotspots and analysis results are stored and served from a python webserver via a documented Application Programming Interface (API, see main text). The webserver also provides the files required for the single page javascript application. (C) Analysis results are provided interactively in the user's web browser (client-side) through a rich, single page javascript application. (D) Examples of potential follow-on applications based on observations made using MutationAligner.