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. 2015 Nov 20;44(Database issue):D239–D247. doi: 10.1093/nar/gkv1258

Table 1. Advances and improvements provided by miRTarBase 6.0.

Features miRTarBase 4.5 miRTarBase 6.0
Release date 2013/11/01 2015/09/15
Curated articles 2636 4966
miRNAs 1232 3786
Target genes 17 520 22 563
Curated miRNA-target interactions 51 460 366 181
miRNA and target gene expression profiles GEO GEO, TCGA (571 data sets, 19 cancer type)
Text-mining technique to prescreen literature Keyword search NLP
Abstract annotation data for download None Yes
MTIs were validated by experimental technology Reporter assay, western blot, northern blot, qRT-PCR, microarray, pSILAC, NGS (HITS-CLIP, Degradome-seq and CLASH) Reporter assay, western blot, northern blot, qRT-PCR, microarray, pSILAC, 3′ LIFE, TRAP, NGS (HITS-CLIP, Degradome-seq, CLASH, PAR-CLIP, iPAR-CLIP).
Graphical visualization miRNA, secondary structure, known and novel miRNA target sites, functional and nonfunctional MTIs, experimental conditions, miRNA-target network, upgrade reminder service, error report system, user feedback service, miRNA-target expression profile from GEO. miRNA, secondary structure, known and novel miRNA target sites, functional and non-functional MTIs, experimental conditions, miRNA-target network, upgrade reminder service, user feedback service, miRNA-target expression profile from GEO and TCGA, updated error report system, enhanced search system, word cloud of miRNA-disease information, miRNA-Target site viewer using CLIP-seq data.