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. 2015 Dec 14;112(52):16042–16047. doi: 10.1073/pnas.1514250112

Fig. 6.

Fig. 6.

Musclin signaling improves aerobic capacity and prompts mitochondrial biogenesis. (A) Summary statistics for trend of oxygen consumption over time of exercise-trained mice upon initiation of treadmill exercise at time 0. *P < 0.05 vs. Ostn-KO. (B) Representative electron micrographs of longitudinal tibialis anterior sections from exercised mice. White arrows indicate mitochondria. (C) Summary statistics for mitochondrial content by weight in gastrocnemius isolates of exercised mice. *P < 0.05 vs. WT. (D and E) Representative Western blots of respiratory chain enzymes and GAPDH (D) and summary statistics for respiratory complex expression normalized to GAPDH in gastrocnemius of exercise-trained mice (E). *P < 0.05 vs. WT. (F and G) Representative stains for SDH activity of tibialis anterior cross-sections (F) and summary statistics for percent area of cross-sections stained for SDH activity (G) in exercise-trained mice. *P < 0.05 vs. WT. KO, Ostn-KO.