Fig. S3.

Oxygen consumption of Ostn-KO is rescued by musclin infusion. The oxygen consumption, VO₂, over time upon initiation of treadmill exercise was compared in WT and Ostn-KO mice treated with 3 wk of saline or musclin delivered by osmotic pump. Oxygen consumption of WT mice treated with musclin was slightly better for several time points than that of WT mice treated with saline. Oxygen consumption of Ostn-KO mice treated with musclin is equivalent to that of WT mice treated with musclin and was better than WT treated with saline once steady state was achieved. *P < 0.05 for WT + musclin vs. WT + saline; ^§P < 0.05 for Ostn-KO + musclin vs. WT + saline.