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. 2015 Dec 14;112(52):E7230–E7238. doi: 10.1073/pnas.1507459112

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Fig. 3. — CARD11(L225LI)-mediated B-cell activation strictly depends on BCL10 and MALT1. (A) Anti-CK1α immunoprecipitation using lysates from B lymphocytes of 5-d-old animals. (B) Kaplan–Meier curves of mice of indicated genotypes (each genotype, n ≥ 5). (C) Histogram of splenic B cells from 5-d-old CD19-Cre and CARD11(L225LI)^CD19-Cre mice. (D) Histogram of splenic B cells from 2- to 3-mo-old CD19-Cre;BCL10^+/−, CD19-Cre;BCL10^−/−, and CARD11(L225LI)^CD19-Cre;BCL10^−/− mice. (E) CD19-Cre;MALT1^+/−, CD19-Cre;MALT1^−/−, and CARD11(L225LI)^CD19-Cre;MALT1^−/− mice. In C–E, expression of activation markers was assessed by flow cytometry; the analysis was performed in three independent experiments; n ≥ 4 per genotype.