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(a) The transcriptional factors and main targets of the miR-302/367 cluster. The transcriptional regulators in the left upper corner have been functionally validated; dark arrows depict upregulation; black lines indicate repression. TFs in the right upper corner were newly identified by the ENCODE project and the relationship of most of them to the miR-302/367 cluster is putative. (b) Proposed mechanism of miR-302 members' mediation of cell cycle regulation.
