Table 1. Description of non-dimensionalized parameter values used in our simulations.
Parameter | Description | Value | Reference |
---|---|---|---|
Adhesion parameter between cells in same compartment | 0.12 | [22] | |
Reference adhesion parameter for asymmetry simulations | 0.12 | [22] | |
Adhesion parameter between cells in different compartments | 2 × 0.12 | [6] | |
Cell perimeter contractility | 0.04 | [22] | |
Reference perimeter contractility for asymmetry simulations | 0.04 | [22] | |
Δt′ | Time step | 0.01 | [31] |
T2 transition threshold | 0.001 | [31] | |
T1 swap threshold | 0.01 | [31] | |
Distance between new edge nodes after swaps | 1.05 | [31] | |
t wt | End time of the simulation for wt and en>dap | 800 | – |
t CycE | End time of the simulation for en>CycE | 1400 | – |
Time when first round of divisions finishes | 600 | – | |
Time when second round of divisions starts in en>CycE | 600 | – | |
Time when second round of divisions finishes in en>CycE | 1200 | – | |
A ′s | Initial cell area | 1.0 | [22] |
Initial cell target area | 1.0 | [22] | |
Initial cell number inside P compartment | 24 | [14] | |
Initial cell number inside A compartment | 64 | [14] | |
P dap | Probability for P cells to not divide in en>dap | 0.6 | [14] |
P CycE | Probability for P cells to divide twice in en>CycE | 0.54 | [14] |
R A | Ratio between target areas of mother cells and daughter cells | 0.5 | – |
λA | Area asymmetry | 0.0 | – |
λl | Line tension asymmetry | 0.0 | – |
λp | Perimeter asymmetry | 0.0 | – |
For parameter values for which no reference is given, please see main text for details on how these values were estimated.