Table 3.
Three-Year Conditional Disease-Free Survival From Years 0 to 5 After Surgery
| Variable | 3-y Conditional Disease-Free Survival, % | |||||
|---|---|---|---|---|---|---|
| 0 y | 1 y | 2 y | 3 y | 4 y | 5 y | |
| Modified NIH criteria | ||||||
| Very low risk | 91 | 92 | 92 | 92 | 100 | 100 |
| Low risk | 95 | 91 | 90 | 90 | 97 | 100 |
| Intermediate risk | 95 | 90 | 92 | 94 | 92 | 79 |
| High risk | 65 | 68 | 71 | 85 | 83 | 94 |
| MSKCC GIST nomogram | ||||||
| Quartile 4 | 91 | 92 | 92 | 92 | 100 | 100 |
| Quartile 3 | 95 | 91 | 90 | 90 | 97 | 100 |
| Quartile 2 | 94 | 90 | 91 | 95 | 92 | 79 |
| Quartile 1 | 62 | 65 | 68 | 83 | 82 | 94 |
| Tumor size, cm | ||||||
| <5.0 | 95 | 92 | 92 | 92 | 98 | 100 |
| 5.0–10.0 | 80 | 78 | 80 | 88 | 89 | 85 |
| >10.0 | 62 | 64 | 69 | 83 | 81 | 90 |
| Tumor site | ||||||
| Gastric | 85 | 85 | 88 | 93 | 91 | 90 |
| Nongastric | 78 | 74 | 69 | 77 | 87 | 100 |
| Mitotic rate, per 50 HPFs | ||||||
| ≤5 | 93 | 91 | 91 | 92 | 94 | 91 |
| 6–10 | 85 | 88 | 88 | 92 | 92 | 100 |
| >10 | 48 | 50 | 55 | 74 | 69 | 83 |
Abbreviations: GIST, gastrointestinal stromal tumor; HPFs, high-power fields; MSKCC, Memorial Sloan Kettering Cancer Center; NIH, National Institutes of Health; TKI, tyrosine kinase inhibitor.