Table 4. Partial Correlation Coefficients Between Rates of Change in GCIP Thickness and MRI-Derived Measures Stratified by MS Subtype and ON Model^a.

MS Subtype	ON Modela	Cortical GM	Cerebral WM	Thalamus	Caudate	Putamen	Brainstem	CVF
Total
Model 1: n = 107	Model 1	0.361	0.275	0.380	0.163	0.147	0.202	0.437
Model 2: n = 95	Model 2	0.416	0.267	0.245	0.070	0.100	0.300	0.492
Model 3: n = 59	Model 3	0.500	0.433	0.351	0.070	0.225	0.355	0.614
RRMS
Model 1: n = 71	Model 1	0.312	0.201	0.466	0.265	0.131	0.111	0.328
Model 2: n = 61	Model 2	0.431	0.211	0.296	0.182	0.085	0.291	0.450
Model 3: n = 32	Model 3	0.575	0.334	0.575	0.299	0.375	0.353	0.602
Progressive MS
Model 1: n = 36	Model 1	0.528	0.619	0.270	−0.211	0.090	0.305	0.673
Model 2: n = 34	Model 2	0.546	0.583	0.286	−0.154	0.127	0.293	0.670
Model 3: n = 27	Model 3	0.535	0.637	0.355	−0.285	0.110	0.261	0.677

^aAll models were adjusted for baseline age, sex, and disease duration. Model 1 uses the average of the rates of retinal layer thickness change from both eyes, regardless of ON history, but is additionally adjusted for a past history of ON. Model 2 excludes eyes with a past history of ON from the calculation of the rate of change of retinal layer thickness. Model 3 excludes subjects with a previous history of ON in either eye.

CVF = cerebral volume fraction; GCIP = ganglion cell and inner plexiform layers; GM = gray matter; MRI = magnetic resonance imaging; ON = optic neuritis; RRMS = relapsing-remitting multiple sclerosis; WM = white matter.