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Overall and disease-specific survival by NF1 genetic alterations (loss) from the TCGA dataset. NF1 genetic loss shows no effect in overall (A) or disease-specific survival (B) in glioblastoma. However, in the lower-grade glioma group, NF1 loss was associated with significantly worse overall (C) and disease-specific survival (D) (log-rank test). (WT = wild type; NF1 loss includes homozygous deletions and predominantly mutations with functional consequences).
