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. Author manuscript; available in PMC: 2016 Dec 21.
Published in final edited form as: Chem Res Toxicol. 2015 Dec 3;28(12):2400–2410. doi: 10.1021/acs.chemrestox.5b00405

TABLE 1.

Pharmacokinetic parameters for plasma AαC and its metabolites in LCN, IECN and WT mice at a high dose of AαC (13.6 mg/kg)1

Strain Analytes Tmax
(h)		 Cmax
(ng/ml)		 t1/2
(h)		 AUC0-24h
(h*ng/ml)		 CL/F
(ml/h)
WT AαC 1.0 ± 0 26.5 ± 8.6 3.0 ± 2.4 57.6 ± 14.2 6900 ± 1850
LCN AαC 1.0 ± 0 272 ±
85.9a 		2.8 ± 0.3 1360 ± 595a 335 ± 146b
IECN AαC 1.0 ± 0 25.1 ±
12.4		 3.9 ± 2.2 68.4 ± 18.2 5920 ± 1530
WT AαC-N2-Glu 1.0 ± 0 40.2 ± 9.6 1.5 ± 0.7 128 ± 26.8 3610 ± 566
LCN AαC-N2-Glu 1.0 ± 0 186 ±
85.0b 		2.1 ± 0.5 803 ± 241a 543 ± 148a
IECN AαC-N2-Glu 1.8 ± 1.2 42.4 ±
15.4		 2.5 ± 2.2 150 ± 30.0 3180 ± 1031
WT AαC-3-OSO3H 1.8 ± 1.3 669 ± 251 3.4 ± 1.2 3700 ± 911 107 ± 27.9
LCN AαC-3-OSO3H 3.5 ± 2.3 586 ± 128 3.1 ± 0.2 6140 ± 1330b 64.3 ± 13.6a
IECN AαC-3-OSO3H 1.8 ± 1.2 913 ± 248 2.8 ± 0.2 5310 ± 1650 77.0 ± 20.3c
1

Plasma levels of AαC, AαC-N2-Glu, AαC-3-OSO3H were determined after a single dose of AαC at 13.6 mg/kg via oral gavage. Plasma samples were obtained at various times after dosing. Values represent means ± S.D. (n = 5).

a

p < 0.001;

b

p < 0.01;

c

p < 0.05 compared to the corresponding WT group (Student’s t-test or Mann-Whitney Rank test )