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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Aug 17;1848(11 0 0):2985–2997. doi: 10.1016/j.bbamem.2015.08.008

Figure 5.

Figure 5

The voltage dependent open (activated) probability (Q-V curve) obtained using the CG model of voltage coupling (see Fig. 4A) with pλ(V) ∝ exp(−Δfλ(V)). The lease square fit of the voltage dependent open (final state) probability density of Eq. (58) to the analytic form of Q-V curve of Eq. (59) yields the half voltage (V1/2) of ~ −9.2mV and gating charge of ~− 0.78e, resulting in the chemical component of free energy of ~0.2 kcal/mol using ΔGc≡g0(0)− g1(0))=QgV1/2. As expected from Eq. (21), ΔGc is approximately equal to the free energy difference (~0.2 kcal/mol) between the two equilibrium conformational states along a reaction coordinate of voltage activation, i.e., Δf1(V1,min)−Δf1(V0,min).