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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Aug 17;1848(11 0 0):2985–2997. doi: 10.1016/j.bbamem.2015.08.008

Figure 6.

Figure 6

Schematic illustrations of the quantitative correlation between free energy landscapes (parabolas) and a Q-V curve. (A) The stabilization of an open activated state, for example, upon mutations and dug binding, leads to a left shift (toward hyperpolarization) in the Q-V curve (C). (B) The destabilization of a closed resting state also results in the same shift in the Q-V curve. The shift in the Q-V curve in terms of V1/2 is correlated with the stabilization or destabilization of the conformational states, with a quantitative relation of the form, QgΔV1/2≈ΔΔGconf (see Eq. 20).