Table 4.
Cytotoxic Activity (IC50 μM) in Cancer Cell Lines
| IC50 (μM) |
|||
|---|---|---|---|
| compound | MDA-MB-435 | MDA-MB-231 | OVCAR3 |
| Icacinol | 1.25* | 7.30 | 7.55 |
| Humirianthol | 1.65* | 3.74 | 4.12 |
| Humirianthenolide C | 0.66* | 0.67 | 1.05 |
| Icacenone | 6.44* | 10.85 | 18.71 |
| Icacinlactone A (1) | > 20 | > 20 | 17.76 |
| Icacinlactone B (2) | > 20 | > 20 | > 20 |
| Icacinlactone C (3) | > 20 | > 20 | > 20 |
| Icacinlactone D (4) | > 20 | > 20 | > 20 |
| Icacinlactone E (5) | > 20 | > 20 | > 20 |
| Icacinlactone F (6) | 6.16 | 8.94 | 10.50 |
| Icacinlactone G (7) | > 20 | > 20 | > 20 |
| Vinblastine | 0.49 nM | 8.78 nM | 1.82 nM |
*
cited for comparison6