Fig 2. Observed performance at one year (A₃), with A₁ or A₂ used as the baseline, in the MIG-HD cohort.

SDMT: Symbol Digit Modalities Test; Stroop C, W and C/W: Stroop color, word and color/word interference; MDRS: Mattis Dementia Rating Scale; TMT A, B: Trail-Making Test A and B; TFC: Total Functional Capacity; IS: Independence Scale; FAS: Functional Assessment Scale. The red curve represents the baseline (reference score). The blue (or green) curve corresponds to the mean relative score one year later (A₃), with A₁ (or A₂ for the green curve) used as the baseline. A green curve within the blue curve indicates that the decline was easier to detect if A₂ was used as the baseline, rather than A₁. Paired t-tests, significance: * P<0.05, ** P<0.01, *** P<0.001.